The Antinuclear Antibody (ANA) serum test detects autoantibodies that target components of the cell nucleus. It is widely used as a primary screening tool for autoimmune disorders, including systemic lupus erythematosus (SLE), Sjögren’s syndrome, scleroderma, and mixed connective tissue disease. A positive ANA result may prompt further specific antibody testing to confirm diagnosis and guide treatment strategies in rheumatologic and systemic autoimmune conditions.
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