C-reactive protein (CRP) is an acute-phase reactant produced by the liver in response to inflammation, infection, or tissue injury. Quantitative serum CRP measurement aids in detecting and monitoring systemic inflammatory states, assessing cardiovascular risk, and guiding therapy in rheumatologic and infectious diseases.
Parameter Details
Analyte C-reactive protein
Specimen type Serum (5 mL clotted blood in serum separator tube)
Collection & handling Separate serum within 2 h; avoid hemolysis; transport at 2–8 °C; analyze within 24 h or freeze at –20 °C if delayed
Assay methodology High-sensitivity immunoturbidimetric or nephelometric assay
Turn-around time 1 working day
Reference intervals • Standard CRP: < 5 mg/L
• High-sensitivity CRP (hs-CRP): < 1 mg/L (low risk), 1–3 mg/L (moderate), > 3 mg/L (high)
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