Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion, elevated in adenocarcinomas of the colon, pancreas, breast, lung, and ovary. Serum CEA is primarily used to monitor treatment response and detect disease recurrence; it is not recommended for initial cancer screening due to limited sensitivity and specificity.
Parameter Details
Analyte Carcinoembryonic antigen (CEA)
Specimen type Serum (5 mL clotted blood in SST tube)
Collection & handling Separate serum within 2 h; avoid hemolysis; transport at 2–8 °C; freeze at –20 °C if delayed > 48 h
Assay methodology Automated immunoassay (chemiluminescent or enzyme-linked) calibrated to international reference
Turn-around time 1–2 working days
Reference interval ≤ 3 ng/mL (non-smokers); ≤ 5 ng/mL (smokers)
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