Angiotensin Converting Enzyme (ACE) – Serum Test
Purpose:
The ACE test measures the level of angiotensin converting enzyme in the blood. ACE is involved in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. It is also used as a marker for sarcoidosis, a disease involving abnormal collections of inflammatory cells.

Sample Type:
Serum (blood sample)

Why the Test is Done:
To help diagnose or monitor sarcoidosis

To evaluate granulomatous diseases (e.g., tuberculosis, leprosy)

To investigate unexplained high calcium levels or respiratory symptoms

Occasionally used in assessing ACE inhibitor therapy response (though not routinely)

Normal Ranges:
Varies by lab

Typical adult range: 8–52 U/L

Key Notes:
Elevated ACE may suggest active sarcoidosis, but can also occur in other conditions

Decreased ACE can occur in people taking ACE inhibitor medications

Not definitive on its own; results should be interpreted with clinical findings and imaging