17-Ketogenic Steroids (Corticosteroids) – Test Overview

What They Are:
17-Ketogenic steroids are a group of corticosteroid metabolites derived primarily from the adrenal cortex. These include compounds like cortisol and its breakdown products. They're involved in the body's response to stress, metabolism, and immune function.

Sample Type:
24-Hour Urine: Most common for measuring total corticosteroid metabolites over a full day.

Serum (blood): Occasionally used, but less common for total 17-ketogenic steroid analysis.

Purpose of the Test:
To evaluate adrenal cortical function.

Helps diagnose or monitor conditions such as:

Cushing’s syndrome (excess cortisol)

Addison’s disease (cortisol deficiency)

Adrenal tumors or hyperplasia

Congenital adrenal hyperplasia (CAH)

Why Urine Collection Matters:
Steroid levels fluctuate throughout the day, so a 24-hour urine sample provides a more accurate picture than a single blood draw.

High Levels May Indicate:
Cushing’s syndrome

Adrenal tumors

Severe stress

Obesity

Hyperthyroidism

Low Levels May Indicate:
Addison’s disease

Pituitary insufficiency

Adrenal suppression due to steroid therapy

Preparation Tips:
Inform your doctor of any medications, especially steroids, which can affect results.

Avoid strenuous exercise and stress before and during collection.